Career

Proxygen harnesses the cellular protein quality control system to develop therapies against cancer and other life-threatening diseases. We are focused on particular small molecules called “molecular glue degraders” which mediate recruitment of a disease-causing protein to a ubiquitin ligase where it is ubiquitinated and directed to the proteasome for degradation. Hence, instead of merely blocking the function of harmful proteins, molecular glue degraders enable their complete and selective elimination.

Proxygen is located in the VBC6 Startup Labs, a new co-working space for biotech companies embedded in the Vienna Biocenter campus, one of Europe’s hotspots for life sciences. Within this context, Proxygen creates a vibrant, dynamic, and inclusive work environment with a strong emphasis on collaboration and teamwork.

We are looking for an enthusiastic full-time principal scientist medicinal chemistry (f/m/d) excited to join our team.

who we are looking for:

• PhD or equivalent in organic chemistry or medicinal chemistry with a minimum of five years’ experience in an industrial drug discovery environment
• Experience in managing, directing, and prioritizing the work of remote teams of medicinal and synthetic chemists at Contract Research Organizations
• Proven track record of advancing drug discovery programs
• Experience in mentoring and supervision of (a small team of) medicinal chemists
• Proficiency in assessing the IP landscape, and drafting patent applications
• Innovative and creative problem solver
• Excellent organizational skills and attention to detail
• Commitment to goals and a sense of urgency in fulfilling ambitious objectives
• Self‐driven, self‐motivated, flexible, and adaptable, positive & constructive attitude

What your main responsibilities will be:

• Leadership of hit validation, hit-to-lead and lead optimization activities to identify molecular glue degrader compounds having appropriate pharmaceutical properties
• Analysis and evaluation of bioassay and pharmacokinetic datasets to design target compounds
• Design of focused libraries of small molecule glue degrader molecules
• Coordination of various outsourced chemistry activities with multiple local and global partners
• Cross-functional integration with other disciplines internally to advance research projects in a timely fashion

what we offer

• International & multidisciplinary team of scientists consisting of molecular biologists, computational biologists and chemists
• Participation in cutting edge research with the overall goal to improve therapeutic options for cancer patients
• Opportunity to contribute to one of the hottest fields in drug discovery
• Support of professional development according to individual goals and aspirations
• Competitive salary based on the applicant’s skills and experience
• Access to state-of-the-art infrastructure

about vienna

The Austrian capital has come out on top of “the world’s highest quality of living” rankings for the past ten years and recently won “the world’s greenest city” award in 2020.
Reasons for Vienna’s prime positioning include:

• Affordable high-quality housing, reliable and affordable public transport
• International airport with non-stop flights to all major cities in Europe
• First-class public healthcare and public educational system
• Parks, recreational areas and other green spaces constituting 50% of the urban area
• Large variety of cultural facilities and leisure activities inside and outside the city
• Young, international population & very high penetrance of english as a second language

application details

Please submit your comprehensive application, including a detailed letter of motivation and curriculum vitae with contact details of two referees to hr@proxygen.com as a single PDF. Applications will be reviewed on a rolling basis until the position is filled.

Proxygen harnesses the cellular protein quality control system to develop therapies against cancer and other life-threatening diseases. We are focused on particular small molecules called “molecular glue degraders” which mediate recruitment of a disease-causing protein to a ubiquitin ligase where it is ubiquitinated and directed to the proteasome for degradation. Hence, instead of merely blocking the function of harmful proteins, molecular glue degraders enable their complete and selective elimination.

Proxygen is located in the VBC6 Startup Labs, a new co-working space for biotech companies embedded in the Vienna Biocenter campus, one of Europe’s hotspots for life sciences. Within this context, Proxygen creates a vibrant, dynamic, and inclusive work environment with a strong emphasis on collaboration and teamwork.

We are looking for an enthusiastic full-time research technician (f/m/d) excited to join our team.

who we are looking for

• Bachelor’s or master’s degree in the life sciences – candidates with a TA diploma (HTL) will also be considered
• Previous wet-lab experience, in particular familiarity with culturing and genetic engineering of mammalian cell lines, is an advantage
• Experience with chemical or genetic screening is considered a plus
• Proficiency with MS Office and willingness to learn new software applications
• Good written and oral communication skills in English are required
• Excellent organizational skills and attention for detail
• High accuracy, reliability and excellent interpersonal and organizational skills
• Positive attitude, reliability, professionalism, and team player mentality

what your main responsibilities will be

• Handling and manipulation of mammalian cell lines (thaw, freeze and culture cells, genome engineering, cellular assays)
• Planning, execution, and analysis of experiments with focus on molecular biology (e.g. PCR, cloning) and biochemistry methods (e.g. Western blot)
• Sample preparation for large-scale proteomic and genomic experiments
• Assay development and establishment of SOP’s
• Accurate and meticulous recording of work processes and results according to internal documentation practices

what we offer

• International & multidisciplinary team of scientists consisting of molecular biologists, computational biologists and chemists
• Participation in cutting edge research with the overall goal to improve therapeutic options for cancer patients
• Opportunity to contribute to one of the hottest fields in drug discovery
• Support of professional development according to individual goals and aspirations
• Competitive salary based on the applicant’s skills and experience
• Access to state-of-the-art infrastructure

about vienna

The Austrian capital has come out on top of “the world’s highest quality of living” rankings for the past ten years and recently won “the world’s greenest city” award in 2020.
Reasons for Vienna’s prime positioning include:

• Affordable high-quality housing, reliable and affordable public transport
• International airport with non-stop flights to all major cities in Europe
• First-class public healthcare and public educational system
• Parks, recreational areas and other green spaces constituting 50% of the urban area
• Large variety of cultural facilities and leisure activities inside and outside the city
• Young, international population & very high penetrance of english as a second language

We are legally obliged by Austrian law to state a minimum base salary according to the collective agreement for this full-time position (€1957,64 per month, payed out 14 times a year). Salary and conditions will however be commensurate to the experience of the candidate and can be negotiated.

application details

Please submit your comprehensive application, including a detailed letter of motivation and curriculum vitae with contact details of two referees to hr@proxygen.com as a single PDF. Applications will be reviewed on a rolling basis until the position is filled.

Proxygen harnesses the cellular protein quality control system to develop therapies against cancer and other life-threatening diseases. We are focused on particular small molecules called “molecular glue degraders” which mediate recruitment of a disease-causing protein to a ubiquitin ligase where it is ubiquitinated and directed to the proteasome for degradation. Hence, instead of merely blocking the function of harmful proteins, molecular glue degraders enable their complete and selective elimination.

Proxygen is located in the VBC6 Startup Labs, a new co-working space for biotech companies embedded in the Vienna Biocenter campus, one of Europe’s hotspots for life sciences. Within this context, Proxygen creates a vibrant, dynamic, and inclusive work environment with a strong emphasis on collaboration and teamwork.

We are looking for an enthusiastic full-time senior research scientist (f/m/d) excited to join our team.

who we are looking for

• Postdoctoral researcher with a focus on biochemistry, molecular or cell biology
• Solution-oriented, persistent individual with an independent, well-structured and goal-oriented working style
• Proven scientific track record that includes at least one first author publication in one of the aforementioned fields
• Experience in supervision and management of small teams is preferred
• Prior work experience in industry or Biotech is of advantage
• Experience in (high-content) microscopy, functional genomics (including CRISPR/Cas9 screens), chemical screening or proteomics will be considered an advantage
• Familiarity with cancer research or the biology of the ubiquitin-proteasome system is desirable
• Experience in genetic engineering of mammalian cell lines using CRISPR/Cas9 and reporter assay development is preferred
• Fluency in Python and/or R is a plus
• Good written and oral communication skills in English are required
• Excellent organizational skills and attention for detail
• High accuracy, reliability and excellent interpersonal and organizational skills
• Positive attitude, reliability, professionalism, and team player mentality

what your main responsibilities will be

• Implementation, execution and analysis of phenotypic drug screens
• Drug target identification via a combination of (chemical) proteomics and functional genomics, assay development and standardization
• Accurate and meticulous recording of work processes and results according to internal documentation practices
• Leading a team of additional scientists
• Contribution to communication/reporting with external pharma partnerships, internal and external presentations

what we offer

• International & multidisciplinary team of scientists consisting of molecular biologists, computational biologists, and chemists
• Participation in cutting edge research with the overall goal to improve therapeutic options for cancer patients
• Opportunity to contribute to one of the hottest fields in drug discovery
• Support of professional development according to individual goals and aspirations
• Competitive salary based on the applicant’s skills and experience
• Access to state-of-the-art infrastructure

about vienna

The Austrian capital has come out on top of “the world’s highest quality of living” rankings for the past ten years and recently won “the world’s greenest city” award in 2020.
Reasons for Vienna’s prime positioning include:

• Affordable high-quality housing, reliable and affordable public transport
• International airport with non-stop flights to all major cities in Europe
• First-class public healthcare and public educational system
• Parks, recreational areas and other green spaces constituting 50% of the urban area
• Large variety of cultural facilities and leisure activities inside and outside the city
• Young, international population & very high penetrance of english as a second language

Salary and conditions will  be commensurate to the experience of the candidate, starting at EUR 53.000 gross per year.

application details

Please submit your comprehensive application, including a detailed letter of motivation and curriculum vitae with contact details of two referees to hr@proxygen.com as a single PDF. Applications will be reviewed on a rolling basis until the position is filled.