Most drugs are designed to block one specific function of a disease-causing protein. But over 80% of human proteins are not accessible via this approach and are generally considered “undruggable”.
Although many important drivers of disease have been known for decades, they are simply out of reach. Glue degraders circumvent this limitation as they do not rely on the requirements of traditional pharmacology. The right glue degrader can attack any given target protein in the cell and lead to its removal.